Life Science

Product quality and process reliability is essential in regards of pharmaceutical water. LAR analyzers determine contamination reliably in lowest levels meeting international reporting requirements.

Life Science

Water analysis of pharmaceutical water, as Purified Water (PW), Highly Purified Water (HPW) or Water for Injection (WFI) is of special concern in the life science industry regarding product quality and safety in process.

Depending on the respective application, requirements regarding UPW purity are defined in norms as well as pharma regulations (pharmacopoeia).

LAR's Solutions and Beneftis

Online Process Analyzers:

Application-specific water quality analyzers as turnkey solutions for your analytical measuring requirements.
Worldwide Support:

Our Customer Success Team supports you from the first contact to realization and commissioning to after sales services. We care for you!
Effective Water Management:

Using the proper online process instrumentation helps to avoid high costs, e.g. by preventing product losses or losses of heating energy.

Types of Pharmaceutical Water and their Limitations

Depending on its usage pharmaceutical water needs treatment with various filters and/or disinfection (see the schematic pharma water system above). Generally, there are three types of pharma water defined, :

Purified Water (PW) or Aqua Purificata
Highly Purified Water (HPW) or Aqua Valde Purificata
Water for Injection (WFI) or Aqua Ad Iniectabilia

International Pharmacopeias

In pharma industry the production of Purified Water (PW) and the maximum TOC (total organic carbon) level is defined by more than one authority.

The most popular pharmacopeias are:

Chinese Pharmacopoeia (CP),
European Pharmacopoeia (EP),
Indian Pharmacopoeia (IP),
Japanese Pharmacopoeia (JP), and
U.S. Pharmacopeial Convention (USP).

In the pharmaceutical sector water is inter alia used as

Cleaning agent
Excipient
Ingredient
Raw material and much more

Depending on its usage, pharmaceutical water needs a certain purity.
Requirements on water quality and monitoring equipment are high.

Water for injections (WFI) is a demanding application of UPW in the pharmaceutical industry. In the manufacture of any type of active ingredient and medicine, the entire production process, including the cleaning process, is seamlessly monitored.
Highly purified water (HPW) is used as cleaning agent
Ultra-pure water (UPW) is often used as process water for the production of pills, capsules and other oral medication.

Purification of water

Even drinking water or potable water contain organics and other substances in very low concentration
pharmaceutically used water needs to be purified before it is used in manufacturing processes
The treatment of this so-called feedwater or make-up water takes place on-site and is very costly

Comparison of phamaceutical water Limits

	Purified Water		Highly Purified Water		Water for Injection
TOC	USP	EP	USP	EP	USP	EP
TOC	500 ppb	≤ 0,5 mg/l	N/A	≤ 0,5 mg/l	500 ppb	≤ 0,5 mg/l

Oil-in-Water (OIW) Analyzer

LAR's OIW analyzer QuickOIL is a reliable online measurement system for the determination of oil in water. Due to the analyzers' innovative process design the analyzer determines the OIW content directly without dilution or memory effects. Moreover, it is suitable for every kind of oil, fat and grease - a huge advantage against common OIW methods.

Easy. Fast. Reliable.

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Certified Housings for Special Conditions

In petrochemical or chemical plants explosive gasses, vapours or mist can be present. Therefore, LAR offers a wide range of analyzers with tailor made protective housing in accordance to international standards (IEC 60079-14:2007) and regulations (DIN EN 60079-2:2011-11). These stand-alone analyzers do not necessarily require air-conditioned shelters and they are made specifically for the use within hazardous, potentially explosive and corrosive environments.

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TOC Analyzer for Pure Water Applications

AR's TOC analyzer QuickTOC_purity is the most reliable measurement system for pure and ultra pure water applications. Due to a special injection loop, the sample is fully protected against contaminations from ambient air. Hence, the QuickTOC_purity reliably detects the TOC level of pure water.

The combustion leader in TOC analysis provides maximum reliability and availability, hence also profitability for its operators.

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TOC Analyzer for Pure Water Applications

LAR's TOC analyzer QuickTOCtrace is a reliable analyzer for the lowest measuring ranges, which uses uv oxidation and differential conductivity measurement to determine organic contamination, making it ideal for TOC measurement of (ultra-)pure water. It is a compact and intuitive analyzer with a short reaction time - first results are available within 30 seconds.

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TOC AnOnline TOC Analyzer

LAR's TOC analyzer QuickTOC_ultra is the most reliable measurement system for the roughest waste water applications. Due to an unrivaled injection and oxidation technique, the QuickTOC_ultra easily handles sticky, fatty, salty, and high-particle samples unlike other TOC analyzers.

The combustion leader in TOC analysis provides maximum reliability and availability, hence also profitability for its operators.

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Online COD Analyzer

LAR's chemical oxygen demand (COD) analyzer QuickCOD_ultra is an outstanding measurement system for fast and clean COD measurements. Unlike traditional COD analysis methods, the QuickCOD_ultra oxidizes water samples without the need of any hazardous chemicals. Due to the patented high-temperature combustion method, the measurement results are free of chloride inteferences. Moreover, the analyzer easily handles sticky, fatty, salty, and high-particle samples.

Less chemicals. Simple operation. Save money.

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